Association between pathological characteristics and recurrence score by OncotypeDX in resected T1-3 and N0-1 breast cancer: a real-life experience of a North Hungarian regional center.

Introduction: The 21-gene analysis (OncotypeDX) is validated test for pT1-3, pN0-1 with hormone receptor (HR) positive and normal expression of human epidermal growth factor receptor-2 (HER2) breast cancer (BC) to determine the aggressiveness of the disease based on the calculation of Recurrence Score (RS). Methods: In this retrospective study the authors correlated pathological characteristics and Recurrence Score (RS) by traditional statistical methods and Observed Oriented Modeling (OOM) in a realistic cohort of BC patients. Results: OncotypeDX tests were performed in 94 tumour specimens of 90 BC patients. >83% of node-negative (pN0) and >72% of node-positive (pN1) cases could avoid chemotherapy. For pN0 cases, non-parametric correlation and tests demonstrated significant association in eight types of characteristics [progesterone receptor (PR) expression, Ki-67 value, Ki-67 group, PR group, grade, estrogen receptor (ER) expression, Nottingham Prognostic Index (NPI) and Clinical Risk]. For pN1 cases, parametric correlation and tests showed significant association in six characteristic types (number of positive nodes, ER and PR expression, PR group, Ki-67 group and NPI). Based on OOM for pN0 cases, significant associations were established in three characteristics (Ki-67 group, grade and NPI group). For pN1 cases OOM found significant associations in seven characteristics (PR group, PNI, LVI, Ki-67 group, grade, NPI group and number of positive nodes). Conclusion: First in oncology, OOM was applied, which found some other significant characteristics associated with RS than traditional statistical methods. There were few patients, where no clinical associations were found between characteristics and RS contrary to statistically significant differences. Therefore, the results of these statistical analyses can be neither applied for individual cases nor able to provide the bases for screening patients, i.e., whether they need for OncotypeDX testing or not. OncotypeDX still provides a personalised approach in BC.

Some phenomena of the cap-pushing response in honey bees (Apis mellifera spp.).

The cap-pushing response (CPR) is a new free-flying technique used to study learning and memory in honey bees. Bees fly to a target where they push a cap to reveal a hidden food source. When combined with traditional odor and color targets, the CPR technique opens the door to additional choice preference tests in honey bees. To facilitate the use of the CPR technique, three experiments were conducted. Experiment 1 investigates the impact of extended training on the CPR response and its role in extinction. Experiment 2 explores the role of CPR in overshadowing, and Experiment 3 explores the effects of electric shock punishment on the CPR technique. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Manipulating the Alpha Level Cannot Cure Significance Testing.

We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = 0.05 to p = 0.005, is deleterious for the finding of new discoveries and the progress of science. Given that blanket and variable alpha levels both are problematic, it is sensible to dispense with significance testing altogether. There are alternatives that address study design and sample size much more directly than significance testing does; but none of the statistical tools should be taken as the new magic method giving clear-cut mechanical answers. Inference should not be based on single studies at all, but on cumulative evidence from multiple independent studies. When evaluating the strength of the evidence, we should consider, for example, auxiliary assumptions, the strength of the experimental design, and implications for applications. To boil all this down to a binary decision based on a p-value threshold of 0.05, 0.01, 0.005, or anything else, is not acceptable.

Observation-Oriented Modeling: Going Beyond "Is It All a Matter of Chance"?

An alternative to null hypothesis significance testing is presented and discussed. This approach, referred to as observation-oriented modeling, is centered on model building in an effort to explicate the structures and processes believed to generate a set of observations. In terms of analysis, this novel approach complements traditional methods based on means, variances, and covariances with methods of pattern detection and analysis. Using data from a previously published study by Shoda et al., the basic tenets and methods of observation-oriented modeling are demonstrated and compared with traditional methods, particularly with regard to null hypothesis significance testing.

From means and variances to persons and patterns.

A novel approach for conceptualizing and analyzing data from psychological studies is presented and discussed. This approach is centered on model building in an effort to explicate the structures and processes believed to generate a set of observations. These models therefore go beyond the variable-based, path models in use today which are limiting with regard to the types of inferences psychologists can draw from their research. In terms of analysis, the newer approach replaces traditional aggregate statistics such as means, variances, and covariances with methods of pattern detection and analysis. While these methods are person-centered and do not require parametric assumptions, they are both demanding and rigorous. They also provide psychologists with the information needed to draw the primary inference they often wish to make from their research; namely, the inference to best explanation.

A note on Cohen's overlapping proportions of normal distributions.

Social scientists are often interested in computing the proportion of overlap and nonoverlap between two normal distributions that are separated by some magnitude. In his popular book, Statistical Power Analysis for the Behavioral Sciences (1988, 2nd ed.), Jacob Cohen provided a table (Table 2.2.1) for determining such proportions from common values of separation. Unfortunately, Cohen's proportions are inconsistent with his explication of the popular index of effect size, d; and his proportions are underestimates of distributional overlap and overestimates of nonoverlap. The authors explain how Cohen derived his values and then provide a revised, corrected table of proportions that also match values presented elsewhere.

Social reinforcement delays in free-flying honey bees (Apis mellifera L.).

Free-flying honey bees (Apis mellifera L.) reactions were observed when presented with varying schedules of post-reinforcement delays of 0 s, 300 s, or 600 s. We measured inter-visit-interval, response length, inter-response-time, and response rate. Honey bees exposed to these post-reinforcement delay intervals exhibit one of several patterns compared to groups not encountering delays, and had longer inter-visit-intervals. We observed no group differences in inter-response time. Honey bees with higher response rates tended to not finish the experiment. The removal of the delay intervals increased response rates for those subjects that completed the trials.

Toward a brighter future for psychology as an observation oriented science.

Serious criticisms of psychology's research practices and data analysis methods date back to at least the mid-1900s after the Galtonian school of thought had thoroughly triumphed over the Wundtian school. In the wake of Bem's (2011) recent, highly publicized study on psi phenomena in a prestigious journal, psychologists are again raising serious questions about their dominant research script. These concerns are echoed in the current paper, and Observation Oriented Modeling (OOM) is presented as an alternative approach toward data conceptualization and analysis for the social and life sciences. This approach is rooted in philosophical realism and an attitude toward data analysis centered around causality and common sense. Three example studies and accompanying data analyses are presented and discussed to demonstrate a number of OOM's advantages over current researcher practices.

Replicating a simple study of asymmetry in human cognition.

V. A. Lefebvre proposed an algebraic model of self-reflexion in the 1980s, and one of the model's central predictions was that individuals would exhibit a clear asymmetry in their judgments when facing an ambiguous binary choice task. A replication of the results of a 1990 test of Lefebvre's model was attempted by asking individuals to sort pairs of pinto beans into boxes marked as either "good" or "bad." Consistent with the model's predicted frequency of .618, the participants judged the beans to be good with an average frequency of .624. This result was also significantly higher than the frequency expected from random judgments (viz., .50).

Clinical reasoning in neurology: use of the repertory grid technique to investigate the reasoning of an experienced occupational therapist.

BACKGROUND/AIM: The aim of this paper is to describe the use of a structured interview methodology, the repertory grid technique, for investigating the clinical reasoning of an experienced occupational therapist in the domain of upper limb hypertonia as a result of brain injury. METHOD: Repertory grid interviews were completed before and after exposure to a protocol designed to guide clinical reasoning and decision-making in relation to upper limb neurological rehabilitation. Data were subjected to both qualitative and quantitative analyses. RESULTS: Qualitative analysis focussed on clinical reasoning content. Common themes across the pre- and post-exposure interviews were the use of theoretical frameworks and practice models, the significance of clinical expertise, and discrimination of 'broad' and 'specific' aspects, as well as differentiation between 'therapist and client-related' aspects of the clinical situation. Quantitative analysis indicated that for both pre- and post-exposure repertory grids, clinical reasoning was structured in terms of two main concepts. In the pre-exposure grid, these were related to the therapist's role, and to the 'scope' of practice tasks (either broad or specific). In the post-exposure grid the two main concepts were upper limb performance, and client-centred aspects of the therapy process. CONCLUSIONS: The repertory grid technique is proposed as an effective tool for exploring occupational therapy clinical reasoning, based on its capacity for accessing personal frames of reference, and elucidating both the meaning and the structure supporting clinical reasoning.

The structure of novice and expert occupational therapists' clinical reasoning before and after exposure to a domain-specific protocol.

BACKGROUND/AIM: The research aimed to determine the influence of a protocol designed for use in the domain of upper limb hypertonia due to brain injury on novice and expert occupational therapy clinical reasoning. METHOD: Individual, structured repertory grid interviews were completed with 13 novice and eight expert occupational therapists prior to, and following, exposure to a domain-specific clinical reasoning protocol. Data were subjected to quantitative analyses (Principal Components Analysis, Generalised Procrustes Analysis). RESULTS: Novice participants demonstrated statistically significant change in the structure of their clinical reasoning following exposure to the protocol (P < 0.004). Prior to exposure, novices relied on therapy tasks, the problem-solving process, environmental factors and standard practice to structure their reasoning. Following exposure, novices' clinical reasoning changed to more closely reflect experts' reasoning. Thus, a 'structured approach' and (theoretical) practice perspectives became evident. Prior to exposure to the protocol, experts structured reasoning in terms of (personal and theoretical) practice perspectives, therapy tasks and the scope of such tasks (either 'general' or 'specific'). Following exposure, therapist/client collaboration and upper-limb-related constructs emerged as being used to structure experts' reasoning, although these changes were not statistically significant. CONCLUSION: A protocol designed for guiding clinical reasoning in the context of upper limb hypertonia was perceived to be conceptually useful by novice and expert occupational therapists.

Bridging the idiographic-nomothetic divide: a follow-up study.

In a replication and extension of Grice (2004), participants in the current study rated themselves and other known individuals on scales constructed from their own personal constructs and on marker items for the Big Five model personality traits. Confirmatory components analyses revealed excellent fit for the Big Five Model when applied to aggregate trait ratings but highly variable fit when applied to participants' individual ratings. Comparisons of the personal construct and trait ratings indicated an approximate average overlap of only 51%, and additional analyses revealed several factors that contributed to the uniqueness of the personal constructs. These findings were discussed in the context of the idiographic-nomothetic distinction drawn in personality psychology.

Testing an algebraic model of self-reflexion.

Self-reflexion is the conscious process of taking the position of an observer in relation to one's own thoughts, feelings, and experiences. Building on the work of Lefebvre, Lefebvre, and Adams-Webber, we used a formal algebraic model of self-reflexion to derive several predictions regarding the frequencies with which individuals would rate themselves and others positively on bipolar scales anchored by adjective terms. The current results from 108 participants (41 men, 67 women; M age= 20.2 yr.) confirmed two predictions derived from the model. Three other predictions, however, were not supported even though the observed frequencies were close to the predicted values. Although not as promising as results reported by Lefebvre, et al., these mixed findings were interpreted as encouraging support for the validity of Lefebvre's algebraic model of self-reflexion. Differences between the current methods and those from previous investigations were also examined, and methodological implications for further studies were discussed.

The influence of unequal numbers of trials on comparisons of average event-related potentials.

Four studies examined (a) how event-related potentials (ERPs) change as the number of trials averaged increases and (b) the statistical implications of comparing ERPs composed of different numbers of trials. Experiment 1 utilized data from 7-year-old children performing an oddball task. The other three experiments used simulated data with different distributions of P3 peak latency. In all 4 experiments, peak amplitude decreased and the mean amplitude of the 300 to 900 msec interval remained stable as the number of trials averaged increased. The standard deviations of both measures decreased. These data show that the decrease in peak amplitude with increasing numbers of trials that has been found in other studies is not solely due to the elimination of residual noise but is likely to also involve a fundamental aspect of signal averaging and the algorithm used to select peaks. Furthermore, these experiments expose the possibility of statistical errors when investigators compare average ERPs composed of small versus large numbers of trials as is often done when the oddball paradigm is used.

Bridging the idiographic-nomothetic divide in ratings of self and others on the Big Five.

Recent discussions of the idiographic-nomothetic debate were initially reviewed in this paper. Three important issues stemming from this debate were then expounded within the context of Personal Construct Theory and evaluated in an empirical study. Participants were required to rate themselves and people they knew on 25 marker items for the Big Five personality traits and on 12 of their own unique personal constructs. The ratings were analyzed using a number of novel statistical methods, including a simple type of confirmatory factor analysis and an informative graphing procedure. Results indicated that at least half of the statistical information derived from the idiographic, personal construct ratings was unique when compared to ratings on the nomothetic Big Five items. The implications of these methods and results for person-centered and trait conceptualizations of personality were discussed.

Idiogrid: software for the management and analysis of repertory grids.

Idiogrid is a computer program for analyzing repertory grids in both research and applied settings. With this software, which runs under the Windows operating system, grids of virtually any size can be managed and analyzed. Grids can be transformed, manipulated, merged, and subjected to a host of statistical analyses. Descriptive statistics, principal components analysis, grid comparison techniques, and coordinate grid analysis are all available in the software. A number of indices commonly applied to repertory grids are also computed by Idiogrid, such as measures of ordination, cognitive complexity, and intensity. Text output as well as high-resolution graphics are produced by the software, and grids themselves can be exported to other statistical programs for further analysis.

Reliability of coordinate grid data.

The reliability of data obtained from a modified repertory grid procedure was examined. The coordinate grid, developed by Chambers (1983), measures the logical inconsistency and integrative complexity of an individual's view of different people. 56 college students completed two forms of the coordinate grid on each of two testing occasions. Analysis indicated low reliability for measures of both logical inconsistency (r = -.04) and integrative complexity (r = .31) with respect to the people entered into the grid. The test-retest results were better (r = .51 for logical inconsistency; r = .35 for integrative complexity) but still well below acceptable reliability. Hence, generalizations beyond a particular grid may be unwarranted.